Design of clinical cardioprotection trials using CMR: impact of myocardial salvage index and a narrow inclusion window on sample size
نویسندگان
چکیده
Background Cardiac magnetic resonance imaging (CMR) can be used to determine both myocardial infarct (MI) size and myocardium at risk (MaR), enabling assessment of myocardial salvage index (MSI). MI size as assessed by hyperenhancement on late gadolinium enhancement (LGE) has been shown to decrease approximately 25% during the first week after infarction. The aim of this study was to determine to what extent assessment of MSI and a narrow inclusion window affect the number of patients needed to reach sufficient statistical power in a clinical CMR cardioprotection trial.
منابع مشابه
Sample Size in Clinical Cardioprotection Trials Using Myocardial Salvage Index, Infarct Size, or Biochemical Markers as Endpoint
BACKGROUND Cardiac magnetic resonance (CMR) can quantify myocardial infarct (MI) size and myocardium at risk (MaR), enabling assessment of myocardial salvage index (MSI). We assessed how MSI impacts the number of patients needed to reach statistical power in relation to MI size alone and levels of biochemical markers in clinical cardioprotection trials and how scan day affect sample size. MET...
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